McLure Professor of Psychiatry, Radiology, Neurology

Director, Center for Neuromodulation in Depression and Stress (CNDS)

Director, Section on Mood, Anxiety and Trauma

University of Pennsylvania Perelman School of Medicine

Yvette I. Sheline, MD, MS, McLure Professor of Psychiatry and Behavioral Research at the University of Pennsylvania is delivering the 12^th Annual George R. Murphy Limbic Lecture in Psychiatry. Dr. Sheline is known for her pioneering studies, widely-cited in psychiatric literature, of hippocampal volume loss in major depressive disorder (MDD) and the moderating effects of antidepressant treatment. She and her group were also the first to show that depressed patients had overactive responses to emotional face stimuli in fMRI studies of the amygdala, and subsequent work incorporated the effects of comorbid illness, depression effects on white matter tracts, and integrated neuropsychological measures in studies of depression treatment response. Following up on these discoveries, she investigated circuit-related abnormalities in depression, finding increased default mode network activity that was associated with rumination and with depression severity. Her recent research has focused on dimensional aspects of mood dysregulation across disorders with phenotypic characterization using multimodal neuroimaging data across “anxious misery” disorders such as depression, PTSD and anxiety and on brain mechanisms of depression treatment effects. Her most recent work employs neuroimaging to examine treatment effects of transcranial magnetic stimulation (TMS), cognitive behavioral therapy (CBT) and real time fMRI neurofeedback, to explore the development of biomarkers improving personalized interventions. In addition to her highly collaborative work that engages scientists across Penn and the country, she is a respected mentor and teacher.