Facebook
X
LinkedIn
ForwardNovember 6, 2025: Lecture in Brain-Mind Medicine - Genomics Approaches to Enable Systematic Neuroscience
Genomics Approaches to Enable Systematic Neuroscience
Description:
My lecture will introduce new technologies in spatial and single-cell genomics, and how they are being applied to redefine the neuroanatomical structure of the human brain, and to uncover molecular and cellular mechanisms in neuropsychiatric and neurodegenerative diseases.
Target Audience
This program is intended for Psychiatrists, Psychologists, Fellows, Residents, Interns, Social Workers, and Nurses.
Learning Objectives
Upon completion of the activity, participants will be able to:
- Identify and critically evaluate the different genomics-based approaches to characterizing cell types and states in brain tissues.
- Describe recent insights into the overall structure of the brain made by single-cell and spatial genomics.
- Describe and explain how these technologies are being used to uncover cellular vulnerabilities to neurodegeneration and potential mechanisms of neuropsychiatric disease.
SPEAKER(S)
Evan Macosko, MD, PhD
Associate Professor of Psychiatry, Massachusetts General Hospital
Associate Professor of Neurobiology, Harvard Medical School
Core Institute Member, Broad Institute of MIT and Harvard
Evan Macosko, MD, PhD
Evan Macosko is a core institute member and the Edward Scolnick Professor of the Broad Institute of MIT and Harvard, and an associate professor in the Departments of Psychiatry and Neurobiology at Harvard Medical School. He and his lab invent and apply genomics technology to the study of brain diseases, most especially schizophrenia and Parkinson’s disease. Areas of technological focus include developing genomics approaches to measuring gene expression within cells from intact tissue sections, quantifying synaptic connections, and detecting molecular interactions within cells. Macosko began his work in this field as a postdoctoral fellow with the development of Drop-seq, a foundational technique for performing high-throughput single-cell gene expression analysis. His own group has built upon this work to invent Slide-seq and Slide-tags, technologies that enable genomics measurements of single cells at high spatial resolution. The lab has applied these approaches to discover new brain cell types, characterize cellular responses to psychological stress, and identify disease-vulnerable neurons in neurodegenerative disease.
Macosko received an A.B. in chemistry from Harvard College, his M.D. from Weill Cornell Medical College, and a Ph.D. from The Rockefeller University. He is a practicing adult psychiatrist, completing residency training in psychiatry at McLean and Massachusetts General Hospitals. He is a recipient of a Pew Scholars Award, a Merkin Institute Fellowship, and is the co-director of the Broad Center for Human Brain Cell Variation.
Disclosures:
Available Credit
- 1.00 AMA PRA Category 1 Credit™
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of IHP and Massachusetts General Hospital. IHP is accredited by the ACCME to provide continuing medical education for physicians.
IHP designates this Enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
- 1.00 Nursing Contact Hours
Massachusetts General Laws, Chapter 13, sections 13, 14, 14A, 15 and 15D and Chapter 112, sections 74 through 81C authorize the Board of Registration in Nursing to regulate nursing practice and education.
This program meets the requirements of the Massachusetts Board of Registration in Nursing (244 CMR 5.00) for 1.00 contact hours of nursing continuing education credit. Advance practice nurses, please note: Educational activities which meet the requirements of the ACCME (such as this activity) count towards 50% of the nursing requirement for ANCC accreditation.
- 1.00 Social Workers
As a Jointly Accredited Organization, the MGH Institute of Health Professions is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. MGH Institute of Health Professions maintains responsibility for this course. Social workers completing this course receive 1.00 clock hours for continuing education credits.
- 1.00 Participation
This course allows other providers to claim a Participation Certificate upon successful completion of this course.
Participation Certificates will specify the title, location, type of activity, date of activity, and number of AMA PRA Category 1 Credit™ associated with the activity. Providers should check with their regulatory agencies to determine ways in which AMA PRA Category 1 Credit™ may or may not fulfill continuing education requirements. Providers should also consider saving copies of brochures, agenda, and other supporting documents.
- 1.00 Psychologists CE Credit
Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibility for the content of the programs. MGH Institute of Health Professions designates this activity for 1.00 CE credit.
Accreditation
In support of improving patient care, MGH Institute of Health Professions is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.
1.0 Physicians
MGH Institute of Health Professions designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits ™. Physicians should claim only credit commensurate with the extent of their participation in this activity.
1.0 Physician Associates/Assistants
AAPA Credit Designation Statement – Live
MGH Institute of Health Professions has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.
AAPA Credit Designation Statement – Enduring Materials
MGH Institute of Health Professions has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credits. Approval is valid until {Expiration Date). PAs should only claim credit commensurate with the extent of their participation.
1.0 Nursing
MGH Institute of Health Professions designates this activity for 1.0 contact hours for nurses. The American Academy of Nurse Practitioners Certification Board (AANPCB) accepts credit from organizations accredited by the ACCME and ANCC.
1.0 Pharmacists
This activity provides 1.0 contact hours of continuing education credit.
NOTE FOR PHARMACISTS: Upon closing of the electronic evaluation, IHP will upload the pharmacy-related continuing education information to the CPE Monitor within 60 days. Per ACPE rules, IHP does not have access nor the ability to upload credits requested after the evaluation closes. It is the responsibility of the pharmacist or pharmacy technician to provide the correct information [NABP ePID and DOB (in MMDD format)] in order to receive credit for participating in a CE activity.
1.0 Psychologists:
Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibility for the content of the programs. MGH Institute of Health Professions designates this activity for 1.0 CE credit.
1.0 Social Workers
As a Jointly Accredited Organization, MGH Institute of Health Professions is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. MGH Institute of Health Professions maintains responsibility for this course. Social workers completing this course receive 1.0 clock hours for continuing education credits.
1.0 IPCE Credit
This activity was planned by and for the healthcare team, and learners will receive 1.0 Interprofessional Continuing Education (IPCE) credit for learning and change.