October 19, 2023: Non-Endowed Grand Rounds
The Neuropsychopharmacology of Psychedelic Drugs
Psychedelic therapy (in particular with psilocybin, a serotonin 2A receptor partial agonist or ‘classic’ psychedelic) has emerged as a promising novel, rapid, and enduring intervention candidate for the treatment of mood and substance use disorders. I will introduce and define psychedelic drugs, review current evidence for efficacy in patients with mood and substance use disorders, and introduce recent evidence for potential neurocognitive processes associated with cognitive control that may provide a transdiagnostic therapeutic mechanistic target of psilocybin.
This program is intended for: Psychiatrists, Psychologists, Fellows, Residents, Interns and Nurses
Upon completion of the activity, participants will be able to:
- Describe the therapeutic approach currently used with psilocybin.
- Summarize recent findings regarding potential efficacy of psilocybin to treat patients with mood and substance use disorders.
- Discuss the relationship between acute effects and therapeutic effects of psilocybin.
Frederick Barrett, PhD
Frederick Barrett, PhD
Frederick Barrett, Ph.D. is Associate Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine and is the Director of the Johns Hopkins Center for Psychedelic and Consciousness Research. Dr. Barrett has been conducting psychedelic research at Johns Hopkins University since 2013. His research in heathy participants and in patients with mood and substance use disorders focuses on the psychological and neurobiological mechanisms underlying the acute subjective and enduring therapeutic effects of psychedelic drugs. Dr. Barrett has developed scientific instruments and published foundational papers on the psychometric evaluation of both mystical and challenging experiences evoked by psychedelic drugs. He published first-in-human studies of the acute effects of the atypical hallucinogen salvinorin A on the brain, and the persisting effects of the classic psychedelic drug psilocybin on cognition and brain function for weeks and months after a single administration. He has also published first-in-human studies of the effects of psilocybin on a brain structure called the claustrum, which was hypothesized by Francis Crick and Christoph Koch to be the conductor of consciousness. Dr. Barrett has been featured on the TEDMED stage and PBS NOVA, and he has appeared on NPR, CNN, The Associated Press, The Telegraph, The Hill, Scientific American, Discover Magazine, Business Insider, Vogue, Wired, VICE, Nature Outlook, Scripps Research, and local public radio stations throughout the United States and abroad.
- 1.00 AMA PRA Category 1 Credit™
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of McLean Hospital and Massachusetts General Hospital. McLean Hospital is accredited by the ACCME to provide continuing medical education for physicians.
McLean Hospital designates this Enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
- 1.00 Nursing Contact Hours
Massachusetts General Laws, Chapter 13, sections 13, 14, 14A, 15 and 15D and Chapter 112, sections 74 through 81C authorize the Board of Registration in Nursing to regulate nursing practice and education.
This program meets the requirements of the Massachusetts Board of Registration in Nursing (244 CMR 5.00) for 1.00 contact hours of nursing continuing education credit. Advance practice nurses, please note: Educational activities which meet the requirements of the ACCME (such as this activity) count towards 50% of the nursing requirement for ANCC accreditation.
- 1.00 Participation
This course allows other providers to claim a Participation Certificate upon successful completion of this course.
Participation Certificates will specify the title, location, type of activity, date of activity, and number of AMA PRA Category 1 Credit™ associated with the activity. Providers should check with their regulatory agencies to determine ways in which AMA PRA Category 1 Credit™ may or may not fulfill continuing education requirements. Providers should also consider saving copies of brochures, agenda, and other supporting documents.
- 1.00 Psychologists CE Credit
The Massachusetts General Hospital Department of Psychiatry is approved by the American Psychological Association to sponsor continuing education for psychologists. The Massachusetts General Hospital Department of Psychiatry maintains responsibility for this program and its content.
This offering meets the criteria for 1.00 Continuing Education (CE) credits per presentation for psychologists.
In support of improving patient care, MGH Institute of Health Professions is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.
MGH Institute of Health Professions designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits ™. Physicians should claim only credit commensurate with the extent of their participation in this activity.
1.00 Nursing Contact Hours
MGH Institute of Health Professions designates this activity for 1.00 contact hours for nurses.
1.00 Social Workers
As a Jointly Accredited Organization, MGH Institute of Health Professions is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. MGH Institute of Health Professions maintains responsibility for this course. Social workers completing this course receive 1.00 clock hours for continuing education credits.
1.00 IPCE Credit
This activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education (IPCE) credit for learning and change.