April 13, 2023: 13th George B. Murray, M.D., Limbic Lecture in Psychiatry
The Role of Precision in Active Inference and its Clinical Implications
This talk considers formal or computational approaches to psychopathology, using psychosis as a case study in computational psychiatry. We first review the basic phenomenology and pathophysiological theories of schizophrenia, with a special focus on synaptopathy and neuromodulation. It then considers the (neuromodulatory) encoding of uncertainty or precision within predictive coding implementations of active inference to foreground the key role of synaptopathy in hallucinosis and delusion formation.
This program is intended for: Psychiatrists, Psychologists, Fellows, Residents, Interns and Nurses
Upon completion of the activity, participants will be able to:
- Describe early taxonomies of dysconnection in terms of synaptopathy
- Utilize knowledge to formulate hallucinations and delusions in terms of predictive processing and active inference
- Demonstrate the key role of neuromodulatory synaptopathy in underwriting hallucinations and delusions
Karl J. Friston, MBBS, MA
Karl J. Friston, MBBS, MA
Karl Friston is a theoretical neuroscientist and authority on brain imaging. He invented statistical parametric mapping (SPM), voxel-based morphometry (VBM) and dynamic causal modelling (DCM). These contributions were motivated by schizophrenia research and theoretical studies of value-learning – formulated as the dysconnection hypothesis of schizophrenia. Mathematical contributions include variational Laplacian procedures and generalized filtering for hierarchical Bayesian model inversion. Friston currently works on models of functional integration in the human brain and the principles that underlie neuronal interactions. His main contribution to theoretical neurobiology is a free-energy principle for action and perception (active inference).
- 1.00 AMA PRA Category 1 Credit™
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of McLean Hospital and Massachusetts General Hospital. McLean Hospital is accredited by the ACCME to provide continuing medical education for physicians.
McLean Hospital designates this Enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
- 1.00 Nursing Contact Hours
Massachusetts General Laws, Chapter 13, sections 13, 14, 14A, 15 and 15D and Chapter 112, sections 74 through 81C authorize the Board of Registration in Nursing to regulate nursing practice and education.
This program meets the requirements of the Massachusetts Board of Registration in Nursing (244 CMR 5.00) for 1.00 contact hours of nursing continuing education credit. Advance practice nurses, please note: Educational activities which meet the requirements of the ACCME (such as this activity) count towards 50% of the nursing requirement for ANCC accreditation.
- 1.00 Participation
This course allows other providers to claim a Participation Certificate upon successful completion of this course.
Participation Certificates will specify the title, location, type of activity, date of activity, and number of AMA PRA Category 1 Credit™ associated with the activity. Providers should check with their regulatory agencies to determine ways in which AMA PRA Category 1 Credit™ may or may not fulfill continuing education requirements. Providers should also consider saving copies of brochures, agenda, and other supporting documents.
- 1.00 Psychologists CE Credit
The Massachusetts General Hospital Department of Psychiatry is approved by the American Psychological Association to sponsor continuing education for psychologists. The Massachusetts General Hospital Department of Psychiatry maintains responsibility for this program and its content.
This offering meets the criteria for 1.00 Continuing Education (CE) credits per presentation for psychologists.