March 30, 2023: 8th Susan N. Sweeney, Lecture in Bipolar Disorder
Circadian Genes, Rhythms and the Biology of Psychiatric Disorders
Circadian rhythm disruptions are crucial to multiple psychiatric disorders, including bipolar disorder. In this presentation, Dr. McClung will speak about her work in both the human postmortem brain and animal models, which is aimed at understanding the molecular rhythm changes in the brain that occur with psychiatric disease and how rhythm disruptions alter cellular activity and behavior.
This program is intended for: Psychiatrists, Psychologists, Fellows, Residents, Interns and Nurses
Upon completion of the activity, participants will be able to:
- Describe the molecular clock and how it works
- Identify a method for measuring molecular rhythms in the human brain
- Explain how changes to the molecular clock are associated with psychiatric disease and behavior
Collen A. McClung, PhD
Colleen A. McClung, Ph.D.
Professor of Psychiatry and Clinical and Translational Science
Director of the Center for Adolescent Reward, Rhythms and Sleep
Translational Neuroscience program and Center for Neuroscience
University of Pittsburgh School of Medicine
Dr. Colleen McClung is a Professor of Psychiatry and Clinical and Translational Science at the University of Pittsburgh School of Medicine and the Director of the NIDA-funded NIH Center for Adolescent Reward, Rhythms and Sleep (CARRS). Dr. McClung’s research program focuses on the role of circadian rhythms in developing and treating psychiatric disorders. Her work has utilized rodent models, cell culture work, and human postmortem tissue to define how circadian genes regulate mood, reward, motivation, anxiety, and other phenotypes associated with bipolar disorder and other psychiatric disorders. She was the first to describe manic-like behaviors in mice with a mutation in the Clock gene, a central component of the circadian clock. These studies have helped us understand the strong relationship between disrupted circadian rhythms and bipolar disorder. Moreover, she has collaborated with multiple pharmaceutical companies, performing preclinical studies to test novel treatments for bipolar disorder and schizophrenia. Some of these compounds are currently in clinical trials. Her more recent work in the human postmortem brain in people with schizophrenia and bipolar disorder has identified specific molecular rhythm changes that will help us develop more targeted therapies. She is the recipient of many awards, including the Colvin Prize for Outstanding Achievement in Mood Disorders Research from the Brain and Behavior Research Foundation, The IMHRO (One Mind)/Johnson & Johnson Rising Star Award. She is an elected member of the ACNP Council.
- 1.00 AMA PRA Category 1 Credit™
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of McLean Hospital and Massachusetts General Hospital. McLean Hospital is accredited by the ACCME to provide continuing medical education for physicians.
McLean Hospital designates this Enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
- 1.00 Nursing Contact Hours
Massachusetts General Laws, Chapter 13, sections 13, 14, 14A, 15 and 15D and Chapter 112, sections 74 through 81C authorize the Board of Registration in Nursing to regulate nursing practice and education.
This program meets the requirements of the Massachusetts Board of Registration in Nursing (244 CMR 5.00) for 1.00 contact hours of nursing continuing education credit. Advance practice nurses, please note: Educational activities which meet the requirements of the ACCME (such as this activity) count towards 50% of the nursing requirement for ANCC accreditation.
- 1.00 Participation
This course allows other providers to claim a Participation Certificate upon successful completion of this course.
Participation Certificates will specify the title, location, type of activity, date of activity, and number of AMA PRA Category 1 Credit™ associated with the activity. Providers should check with their regulatory agencies to determine ways in which AMA PRA Category 1 Credit™ may or may not fulfill continuing education requirements. Providers should also consider saving copies of brochures, agenda, and other supporting documents.
- 1.00 Psychologists CE Credit
The Massachusetts General Hospital Department of Psychiatry is approved by the American Psychological Association to sponsor continuing education for psychologists. The Massachusetts General Hospital Department of Psychiatry maintains responsibility for this program and its content.
This offering meets the criteria for 1.00 Continuing Education (CE) credits per presentation for psychologists.